Austgulen R
Nord Med. 1989;104(1):16-7.
Hematologic growth factors are now assessible in recombinant forms, and thus available in amounts making cliical use possible. Erythropoietin, which induces differentiation and proliferation of the red blood cells, is produced by recombinant techniques. Clinical trials have shown the effectiveness of erythropoietin in correcting the anaemia of end stage renal diseare in patients maintained by haemodialysis. One of the growth factors for white blood cells, so called colony stimulating factors (CSF) has been given to patients suffering from AIDS. The growth factor given (GM-CSF) has a stimulatory effect upon granulocytes as well as monocytes. The clinical trial showed that the low white cell counts of the patients were normalized in a dose-dependent manner after GM-CSF administration. Clinical studies are under way. Erythropoietin, GM-CSF and G-CSF (stimulates granulocytes) are now being tested at medical centers in patients with AIDS, various forms of anemia, cancer and bone marrow transplants.
血液学生长因子现在有了重组形式，因此有了足以用于临床的量。促红细胞生成素可诱导红细胞分化和增殖，它是通过重组技术生产的。临床试验已表明促红细胞生成素对接受血液透析维持治疗的终末期肾病患者纠正贫血有效。白细胞生长因子之一，即所谓的集落刺激因子（CSF）已用于艾滋病患者。所给予的生长因子（GM-CSF）对粒细胞和单核细胞均有刺激作用。临床试验表明，给予GM-CSF后，患者的低白细胞计数呈剂量依赖性恢复正常。临床研究正在进行中。促红细胞生成素、GM-CSF和G-CSF（刺激粒细胞）目前正在医疗中心对艾滋病患者、各种贫血患者、癌症患者和骨髓移植患者进行测试。
