Meza-Gutierrez Fernando, Hundley Frances V, Toczyski David P
Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
Mol Cell. 2015 Oct 1;60(1):3-4. doi: 10.1016/j.molcel.2015.09.015.
CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
CDC20和CDH1是后期促进复合体/细胞周期体(APC/C)中已被充分证实的底物受体。在本期《分子细胞》杂志中,Lee等人(2015年)表明,这些衔接蛋白还可以通过另一种泛素连接酶帕金,将细胞周期蛋白靶向降解。