Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
Semin Cell Dev Biol. 2011 Aug;22(6):579-85. doi: 10.1016/j.semcdb.2011.03.012. Epub 2011 Apr 7.
The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/C(Cdh1) in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/C(Cdh1) in regulating crucial events during development.
APC/C（有丝分裂促进复合物/细胞周期素体）的功能最初与有丝分裂中期的后期起始有关，在此期间，它与 Cdc20 靶标 securin 结合并将其破坏，从而使两个复制的子基因组分离。当与 Cdh1 结合时，APC 调节细胞周期中的 G1/S 转换和 DNA 复制。除了细胞周期控制之外，最近的生化和小鼠遗传学研究结果引起了我们对 APC/C（Cdh1）在细胞分化、基因组完整性和各种疾病发病机制中的意外影响的关注。本综述旨在总结目前对 APC/C（Cdh1）在调节发育过程中关键事件的理解。
