Reinstein Dan Z, Archer Timothy J, Gobbe Marine, Bartoli Elena
From the London Vision Clinic (Reinstein, Archer, Gobbe), London, United Kingdom; the Department of Ophthalmology (Reinstein), Columbia University Medical Center, New York, New York, USA; Centre Hospitalier National d'Ophtalmologie (Reinstein), Paris, France; Laser SRL Refractive Laser Center (Bartoli), Torino, Italy.
From the London Vision Clinic (Reinstein, Archer, Gobbe), London, United Kingdom; the Department of Ophthalmology (Reinstein), Columbia University Medical Center, New York, New York, USA; Centre Hospitalier National d'Ophtalmologie (Reinstein), Paris, France; Laser SRL Refractive Laser Center (Bartoli), Torino, Italy.
J Cataract Refract Surg. 2015 Aug;41(8):1580-7. doi: 10.1016/j.jcrs.2014.12.055.
To longitudinally evaluate corneal sensitivity after small-incision lenticule extraction and compare the results with those in previous studies.
London Vision Clinic, London, United Kingdom.
Retrospective case series.
Consecutive myopic eyes treated with small-incision lenticule extraction using the Visumax femtosecond laser were studied. Corneal sensitivity was measured centrally and at 4 paracentral locations using a Cochet-Bonnet esthesiometer preoperatively and 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. Results were compared with averaged results from previous laser in situ keratomileusis (LASIK) and small-incision lenticule extraction studies.
The mean spherical equivalent was -6.85 diopters (D) ± 2.57 (SD). The mean age was 36 ± 11 years. After small-incision lenticule extraction, the preoperative mean central corneal sensitivity dropped from 54 mm preoperatively to 33 mm 1 day postoperatively, rising to 40 mm, 45 mm, 48 mm, 54 mm, and 55 mm over 12 months; it reached baseline at 6 months (P > .05). For 21 LASIK studies, the mean central corneal sensitivity dropped from 56 mm preoperatively to 6 mm at 1 day, rising to 14 mm, 23 mm, 34 mm, 45 mm, and 51 mm over 12 months. For 8 small-incision lenticule extraction studies, central corneal sensitivity dropped from 57 mm preoperatively to 39 mm at 1 week, then rose to 39 mm, 42 mm, 49 mm, 52 mm, and 54 mm over 12 months; it was higher than after LASIK at 1 week and 1, 3, and 6 months (P < .05).
Recovery of central corneal sensitivity to baseline was reached by 6 months after small-incision lenticule extraction and was higher than after LASIK for the first 6 months after surgery.
Dr. Reinstein is a consultant to Carl Zeiss Meditec AG, has a proprietary interest in the Artemis technology (Arcscan, Inc.), and is an author of patents related to very high-frequency digital ultrasound administered by the Center for Technology Licensing at Cornell University, Ithaca, New York, USA. No other author has a financial or proprietary interest in any material or method mentioned.
纵向评估小切口透镜切除术（small-incision lenticule extraction）后角膜敏感性，并将结果与先前研究进行比较。
英国伦敦伦敦视力诊所。
回顾性病例系列。
研究连续接受使用Visumax飞秒激光进行小切口透镜切除术治疗的近视眼睛。术前以及术后1天、1周、1、3、6和12个月，使用Cochet-Bonnet触觉计在角膜中央和4个旁中央位置测量角膜敏感性。将结果与先前准分子原位角膜磨镶术（laser in situ keratomileusis，LASIK）和小切口透镜切除术研究的平均结果进行比较。
平均等效球镜度为-6.85屈光度（D）±2.57（标准差）。平均年龄为36±11岁。小切口透镜切除术后，术前平均中央角膜敏感性从术前的54毫米降至术后1天的33毫米，在12个月内升至40毫米、45毫米、48毫米、54毫米和55毫米；在6个月时恢复至基线水平（P>.05）。对于21项LASIK研究，平均中央角膜敏感性从术前的56毫米降至术后1天的6毫米，在12个月内升至14毫米、23毫米、34毫米、45毫米和51毫米。对于8项小切口透镜切除术研究，中央角膜敏感性从术前的57毫米降至术后1周的39毫米，然后在12个月内升至39毫米、42毫米、49毫米、52毫米和54毫米；在术后1周以及1、3和6个月时高于LASIK术后（P<.05）。
小切口透镜切除术后6个月中央角膜敏感性恢复至基线水平，且在术后前6个月高于LASIK术后。
Reinstein医生是卡尔蔡司医疗技术股份公司（Carl Zeiss Meditec AG）的顾问，对Artemis技术（Arcscan公司）拥有所有权权益，并且是由美国纽约伊萨卡康奈尔大学技术许可中心管理的与超高频数字超声相关专利的作者。其他作者对文中提及的任何材料或方法均无财务或所有权权益。
