通过与环磷酸腺苷磷酸二酯酶PDE4相互作用揭示精神分裂症1基因的功能：豪斯利实验室对分子精神病学的贡献
Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry.
作者信息
Brandon Nicholas J
机构信息
Astrazeneca Neuroscience iMED, 141, Portland St, Cambridge, MA 02139 USA.
出版信息
Cell Signal. 2016 Jul;28(7):749-52. doi: 10.1016/j.cellsig.2015.09.019. Epub 2015 Sep 30.
Abstract
Nearly 10years ago the laboratory of Miles Houslay was part of a collaboration which identified and characterized the interaction between Disrupted in Schizophrenia 1 and phosphodiesterase type 4. This work has had significant impact on our thinking of psychiatric illness causation and the potential for therapeutics.
摘要
近10年前，迈尔斯·豪斯利实验室参与了一项合作，该合作确定并描述了精神分裂症1号基因（Disrupted in Schizophrenia 1）与4型磷酸二酯酶之间的相互作用。这项工作对我们关于精神疾病病因及治疗潜力的思考产生了重大影响。
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