荧光素钠引导下的脑淋巴瘤手术
Fluorescein sodium-guided surgery in cerebral lymphoma.
作者信息
Schebesch Karl-Michael, Hoehne Julius, Hohenberger Christoph, Acerbi Francesco, Broggi Morgan, Proescholdt Martin, Wendl Christina, Riemenschneider Markus J, Brawanski Alexander
机构信息
Department of Neurosurgery, Regensburg University Hospital, Germany; Wilhelm-Sander Neuro-Oncology Unit, Regensburg University Hospital, Germany.
Department of Neurosurgery, Regensburg University Hospital, Germany; Wilhelm-Sander Neuro-Oncology Unit, Regensburg University Hospital, Germany.
出版信息
Clin Neurol Neurosurg. 2015 Dec;139:125-8. doi: 10.1016/j.clineuro.2015.09.015. Epub 2015 Sep 26.
OBJECTIVES
Growth and progress of primary central nervous lymphoma (PCNSL) severely disrupt the blood brain barrier (BBB). Such disruptions can be intraoperatively visualized by injecting fluorescein sodium (FL) and applying a YELLOW 560 nm surgical microscope filter. Here, we report a small cohort of patients with PCNSL that mimicked high grade gliomas (HGG) or cerebral metastases (CM), who had been operated on with the use of FL.
PATIENTS AND METHODS
Retrospectively, seven patients with PCNSL were identified, who had been operated on by means of microsurgery after intravenous FL injection. The surgical reports were screened for statements on the grade of fluorescent staining in the tumor area. One representative case was chosen to show the staining under white light as well as under filtered light at different distances to the tumor area.
RESULTS
All patients had shown bright and homogenous fluorescent staining of the tumor (n=7. 100%). No adverse effects had been observed.
CONCLUSION
Similar to patients with HGG or CM, patients with PCNSL may benefit from use of FL and the dedicated YELLOW 560 nm filter in open surgery.
目的
原发性中枢神经系统淋巴瘤（PCNSL）的生长和进展严重破坏血脑屏障（BBB）。通过注射荧光素钠（FL）并应用560 nm黄色手术显微镜滤光片，可在术中观察到这种破坏。在此，我们报告一小群模仿高级别胶质瘤（HGG）或脑转移瘤（CM）的PCNSL患者，他们接受了使用FL的手术。
患者与方法
回顾性分析，确定7例PCNSL患者，他们在静脉注射FL后接受了显微手术。对手术报告进行筛查，以获取关于肿瘤区域荧光染色分级的描述。选择一个代表性病例，展示在白光以及距肿瘤区域不同距离的滤光下的染色情况。
结果
所有患者的肿瘤均显示明亮且均匀的荧光染色（n = 7，100%）。未观察到不良反应。
结论
与HGG或CM患者相似，PCNSL患者在开放手术中使用FL和专用的560 nm黄色滤光片可能有益。
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