Kempf Werner, Mitteldorf Christina
Kempf und Pfaltz Histologische Diagnostik, Seminarstrasse 1, Zürich CH-8042, Switzerland; Department of Dermatology, University Hospital Zürich, Gloriastrasse 31 Zürich CH-8091, Switzerland.
Department of Dermatology, HELIOS Kliniken GmbH, Senator-Brawn-Allee 33, 31135 Hildesheim, Germany.
Dermatol Clin. 2015 Oct;33(4):655-81. doi: 10.1016/j.det.2015.05.002. Epub 2015 Aug 18.
Primary cutaneous lymphomas comprise a prognostically heterogeneous group of lymphocytic skin neoplasms, which display a broad spectrum of clinical, histologic, immunophenotypic, and genetic features. The histopathological examination plays an essential role and is often the starting point in the diagnostic workup of cutaneous lymphomas. In most cases, the histopathological and the phenotypic analysis alone are limited to provide a list of differential diagnoses. As a consequence of overlapping clinical, histologic, phenotypic, and genetic features among several entities of cutaneous lymphomas, the clinicopathological correlation is of utmost importance to achieve the final diagnosis.
原发性皮肤淋巴瘤是一组预后异质性的淋巴细胞性皮肤肿瘤，具有广泛的临床、组织学、免疫表型和遗传学特征。组织病理学检查起着至关重要的作用，通常是皮肤淋巴瘤诊断检查的起点。在大多数情况下，仅组织病理学和表型分析只能提供一份鉴别诊断清单。由于几种皮肤淋巴瘤实体之间存在临床、组织学、表型和遗传学特征的重叠，临床病理相关性对于做出最终诊断至关重要。
