Chondros Κ, Karpathakis Ν, Heretis Ι, Mavromanolakis Ε, Chondros N, Sofras F, Mamoulakis C
Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
Hippokratia. 2015 Jan-Mar;19(1):30-3.
Different treatment options for patients with prostate cancer (PCa) are applicable after stratifying patients according to various classification criteria. The purpose of our study is to evaluate the revised Epstein's criteria for insignificant PCa prediction in a Greek subpopulation.
During a 4-year-period, 172 Cretan patients were submitted to radical retropubic prostatectomy in our institution. 23 out of them met the revised Epstein's criteria for the presence of clinically insignificant PCa (clinical stage T1c, prostate specific antigen density < 0.15 ng/ml/g, absence of Gleason pattern 4-5, <3 positive biopsy cores, presence of <50% tumor per core) during pre-treatment evaluation and were retrospectively included in the study. Post-surgery outcomes were evaluated including pathological stage, surgical margins and Gleason score upgrade.
Organ confined disease and insignificant PCa were predicted with a 74% and 31% accuracy, respectively. These figures are remarkably lower than those derived from similar studies worldwide.
Due to the high variation in the revised Epstein's criteria prediction accuracy observed worldwide, the development and implementation of novel tools/nomograms with a greater predictive accuracy is still warranted. Hippokratia 2015, 19 (1): 30-33.
前列腺癌（PCa）患者的不同治疗方案适用于根据各种分类标准对患者进行分层后。我们研究的目的是在希腊亚人群中评估修订后的爱泼斯坦标准对微小前列腺癌预测的效果。
在4年期间，172名克里特岛患者在我们机构接受了耻骨后根治性前列腺切除术。其中23名患者在治疗前评估中符合修订后的爱泼斯坦标准，即存在临床微小前列腺癌（临床分期T1c，前列腺特异性抗原密度<0.15 ng/ml/g，无Gleason 4-5级模式，阳性活检核心<3个，每个核心肿瘤<50%），并被回顾性纳入研究。评估术后结果，包括病理分期、手术切缘和Gleason评分升级。
器官局限性疾病和微小前列腺癌的预测准确率分别为74%和31%。这些数字明显低于全球类似研究得出的数字。
由于全球范围内观察到修订后的爱泼斯坦标准预测准确率差异很大，因此仍有必要开发和实施具有更高预测准确率的新型工具/列线图。《希波克拉底》2015年，第19卷（第1期）：30 - 33页。
