Togral G, Arıkan M, Benzer E, Gungor S
Department of Orthopaedics and Traumatology, Ankara, Turkey.
Department of Pathology, Oncology Training and Research Hospital, Ankara, Turkey.
Hippokratia. 2015 Jan-Mar;19(1):82-4.
Ewing's sarcoma localized to foot is extremely rare. Local control is mandatory because of the aggressive nature of the tumor. Therapeutic options for these local tumors include neoadjuvant chemotherapy followed by surgery.
A 17-year-old female patient presented with a 6-month history of progressive swelling and intermittent pain of the left great toe. Plain radiography and magnetic resonance imaging revealed an expansile mass that had originated from the proximal phalanx of the great toe and was destructing and surrounding the distal phalanx. Her erythrocyte sedimentation rate and serum lactate dehydrogenase levels were slightly elevated. Distant metastasis was not detected. The patient underwent an open biopsy, which confirmed the diagnosis of Ewing's sarcoma. She was treated with neoadjuvant chemotherapy and disarticulation above the metatarsophalangeal joint. She received adjuvant chemotherapy following the operation. The patient died 50 months after the operation as a result of disseminated disease.
The distal phalanx of the foot is an extremely rare site for the development of Ewing's sarcoma. As local control is important to avoid dissemination of the disease, neoadjuvant chemotherapy followed by amputation or disarticulation of the affected digit and subsequently adjuvant chemotherapy may be favorable modality for increasing the patient's duration of survival. Hippokratia 2015, 19 (1): 82-84.
局限于足部的尤因肉瘤极为罕见。由于肿瘤具有侵袭性，局部控制至关重要。这些局部肿瘤的治疗选择包括新辅助化疗后手术。
一名17岁女性患者，有6个月左拇趾进行性肿胀和间歇性疼痛病史。X线平片和磁共振成像显示一个膨胀性肿块，起源于拇趾近节趾骨，正在破坏并包绕远节趾骨。她的红细胞沉降率和血清乳酸脱氢酶水平略有升高。未检测到远处转移。患者接受了切开活检，确诊为尤因肉瘤。她接受了新辅助化疗，并在跖趾关节上方进行了关节离断术。术后接受了辅助化疗。患者术后50个月因疾病播散死亡。
足部远节趾骨是尤因肉瘤极为罕见的发病部位。由于局部控制对于避免疾病播散很重要，新辅助化疗后对患指进行截肢或关节离断术，随后进行辅助化疗，可能是延长患者生存时间的有利方式。《希波克拉底》2015年，第19卷（第1期）：82 - 84页。
