Phatlhane Dineo V, Zemlin Annalise E
Department of Chemical Pathology, National Health Laboratory Service (NHLS) and University of Stellenbosch, Tygerberg Hospital, Cape Town, South Africa.
Ann Hepatol. 2015 Nov-Dec;14(6):924-8. doi: 10.5604/16652681.1171785.
Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile.
脂蛋白X（LpX）是一种与胆汁淤积相关的异常脂蛋白。它是严重高胆固醇血症的重要原因，在胆汁淤积性肝病患者中应始终予以考虑。本病例突出了LpX作为一名继发于结核所致肉芽肿性肝炎的胆汁淤积患者严重高胆固醇血症病因的重要性。进行了脂蛋白琼脂糖凝胶电泳和梯度凝胶电泳以检测LpX。还测定了肝功能、电解质、血脂谱和胆汁酸。开始抗结核治疗，肝功能改善，血脂谱恢复正常。
