Toyoda Tomomi, Terao Yoshiaki, Oji Makito, Okada Mai, Araki Hiroko, Fukusaki Makoto
Masui. 2015 Jun;64(6):580-5.
Droperidol is an effective antiemetic, but its use is limited because of the warning of drug-induced QT prolongation. Some reports showed that low-dose droperidol does not significantly probing QT interval. This study was aimed to determine the effect of low-dose droperidol (1.25 and 2.5 mg) on QTc interval, and the interaction among droperidol, propofol and sevoflurane.
Patients received either 1.25 mg (group L : n = 25) or 2.5 mg (group H : n = 25) droperidol, and fentanyl (3 μg x kg(-1)) was administered 2.5 min later. One minute after fentanyl administration, anesthesia was induced using propofol (1.5 mg x kg(-1)) and vecuronium. One minute after propofol administration, sevoflurane (3%) was started. Tracheal intubation was performed 3 min after propofol administration, and then sevoflurane was reduced to 1%.
Compared to baseline, the QTc interval in group L was unchanged by droperidol. In group H, the QTc interval was significantly prolonged after droperidol injection, but recovered after propofol injection. After tracheal intubation, QTc interval was significantly prolonged in both groups.
Droperidol's effect on QTc prolongation was shown at the dose of 2.5 mg but not 1.25 mg. This prolongation effect was offset by propofol, and was unchanged by sevoflurane.
氟哌利多是一种有效的止吐药，但由于有药物诱导QT间期延长的警告，其应用受到限制。一些报告显示，低剂量氟哌利多不会显著延长QT间期。本研究旨在确定低剂量氟哌利多（1.25毫克和2.5毫克）对QTc间期的影响，以及氟哌利多、丙泊酚和七氟醚之间的相互作用。
患者分别接受1.25毫克（L组：n = 25）或2.5毫克（H组：n = 25）氟哌利多，2.5分钟后给予芬太尼（3微克/千克）。芬太尼给药1分钟后，用丙泊酚（1.5毫克/千克）和维库溴铵诱导麻醉。丙泊酚给药1分钟后，开始给予七氟醚（3%）。丙泊酚给药3分钟后进行气管插管，然后将七氟醚降至1%。
与基线相比，L组氟哌利多未改变QTc间期。在H组中，注射氟哌利多后QTc间期显著延长，但注射丙泊酚后恢复。气管插管后，两组的QTc间期均显著延长。
氟哌利多在2.5毫克剂量时显示出对QTc延长的作用，但在1.25毫克剂量时未显示。这种延长作用被丙泊酚抵消，且不受七氟醚影响。
