Kohno Yumiko, Koishi Keiko, Nishiyama Tomoki
Masui. 2015 Jun;64(6):660-2.
Malignant hyperthermia occurred 10 hours after surgery in a 72-year-old man who had received emergency laparoscopic cholecystectomy for severe acute cholecystitis with cholelethiasis. He had a high fever (39.4 degrees C) with liver damage before surgery. Anesthesia was induced with propofol and fentanyl and maintained with sevoflurane and epidural block using ropivacaine. Rocuronium was used as a muscle relaxant During surgery, body temperature decreased by cooling the body surface, but tachycardia continued. Ten hours after surgery, body temperature increased to the maximum of 40.6 degrees C and he went into shock. Then another 10 hours later, he developed cardiac arrest He recovered, but 22 hours later, second cardiac arrest occurred. After his second recovery, dantrolene was administered and body temperature decreased. He had hypoxic brain damage, but was dischanged from the hospital after tracheostomy on the 150th hospital day. From his clinical course, especially decrease in body temperature by dantrolene, he was suspected to have developed malignant hyperthermia. We should consider malignant hyperthermia when patient had a severe high fever postoperatively.
一名72岁男性在因严重急性胆囊炎伴胆石症接受急诊腹腔镜胆囊切除术后10小时发生恶性高热。他术前有高热(39.4摄氏度)并伴有肝损伤。麻醉诱导使用丙泊酚和芬太尼,维持使用七氟醚并联合使用罗哌卡因进行硬膜外阻滞。使用罗库溴铵作为肌肉松弛剂。手术期间,通过体表降温体温下降,但心动过速持续存在。术后10小时,体温升至最高40.6摄氏度,患者陷入休克。随后又过了10小时,他发生心脏骤停。他恢复了,但22小时后,再次发生心脏骤停。第二次恢复后,给予丹曲林,体温下降。他有缺氧性脑损伤,但在住院第150天气管切开术后出院。从他的临床病程,尤其是丹曲林使体温下降来看,怀疑他发生了恶性高热。当患者术后出现严重高热时,我们应考虑恶性高热。