Nickels Jonathan D, Katsaras John
Joint Institute for Neutron Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Biology & Soft Matter and Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Subcell Biochem. 2015;71:45-67. doi: 10.1007/978-3-319-19060-0_3.
Water is crucial to the structure and function of biological membranes. In fact, the membrane's basic structural unit, i.e. the lipid bilayer, is self-assembled and stabilized by the so-called hydrophobic effect, whereby lipid molecules unable to hydrogen bond with water aggregate in order to prevent their hydrophobic portions from being exposed to water. However, this is just the beginning of the lipid-bilayer-water relationship. This mutual interaction defines vesicle stability in solution, controls small molecule permeation, and defines the spacing between lamella in multi-lamellar systems, to name a few examples. This chapter will describe the structural and dynamical properties central to these, and other water- lipid bilayer interactions.
水对于生物膜的结构和功能至关重要。事实上，膜的基本结构单元，即脂质双层，是通过所谓的疏水效应自组装并稳定的，在这种效应下，无法与水形成氢键的脂质分子聚集在一起，以防止其疏水部分暴露于水中。然而，这仅仅是脂质双层与水关系的开端。这种相互作用决定了溶液中囊泡的稳定性，控制小分子的渗透，并确定多层系统中层片之间的间距，仅举几例。本章将描述这些以及其他水与脂质双层相互作用所核心的结构和动力学性质。
