Streubel Gundula, Bracken Adrian P
Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
EMBO J. 2015 Dec 2;34(23):2863-4. doi: 10.15252/embj.201592996. Epub 2015 Oct 5.
The Mediator multiprotein complex physically links transcription factors to RNA polymerase II and the basal transcription machinery. While the Mediator complex has been shown to be required for transcriptional initiation and elongation, the understanding of its interplay with histone modifying enzymes and post‐translational modifications remains elusive. In this issue of The EMBO Journal, Yao et al (2015) report that the MED23 subunit of the Mediator complex physically associates with the heterodimeric RNF20/40 E3‐ligase complex to facilitate the monoubiquitylation of histone H2B on gene bodies of actively transcribed genes.
中介体多蛋白复合物在物理上把转录因子与RNA聚合酶II及基础转录机制联系起来。虽然中介体复合物已被证明是转录起始和延伸所必需的，但其与组蛋白修饰酶及翻译后修饰之间相互作用的了解仍不清楚。在本期《EMBO杂志》中，Yao等人（2015年）报道，中介体复合物的MED23亚基在物理上与异二聚体RNF20/40 E3连接酶复合物相关联，以促进活跃转录基因基因体上组蛋白H2B的单泛素化。
