Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Trends Microbiol. 2015 Nov;23(11):668-670. doi: 10.1016/j.tim.2015.09.005. Epub 2015 Oct 1.
A Mycobacterium tuberculosis metA mutant that is auxotrophic for methionine is unlike other auxotrophic mutants of this important species as methionine starvation results in rapid death instead of cessation of growth. Evidence suggests that this phenotype results from starvation affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.
一株结核分枝杆菌 metA 突变体是蛋氨酸营养缺陷型的，与该重要物种的其他营养缺陷型突变体不同，因为蛋氨酸饥饿会导致快速死亡，而不是生长停止。有证据表明，这种表型是由于饥饿影响了利用 S-腺苷甲硫氨酸（除了蛋氨酸之外）的必需途径所致。
