Yuan Bangqing, Shen Hanchao, Lin Li, Su Tonggang, Zhong Shanchuan, Yang Zhao
Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian 350025, China.
Department of Neurology, Yongchuan Hospital, Chongqing Medical, University, Chongqing 402160, China.
J Neuroimmunol. 2015 Oct 15;287:71-5. doi: 10.1016/j.jneuroim.2015.08.002. Epub 2015 Aug 7.
Numerous evidence have shown that microglia mediated inflammation plays a pivotal role in the development of brain injury after intracerebral hemorrhage (ICH). Therefore anti-inflammation therapy represents a potentially promising approach to ICH. Recently, NLRP3 inflammasome was discovered to facilitate the inflammatory response. However, the effect of NLRP3 inflammasome after ICH has not been fully studied. To explore the potential of NLRP3 inflammasome, we detected NLRP3 expression, inflammation, brain edema and neurological functions in vitro and in vivo. We found that ICH activated the NLRP3 inflammasome and inflammation. However, NLRP3 RNAi could attenuate inflammation and brain injury after ICH. Therefore, the findings suggested that recombinant adenovirus encoding NLRP3 RNAi might be valuable as a potential strategy for anti-inflammation therapy in ICH.
大量证据表明，小胶质细胞介导的炎症在脑出血（ICH）后脑损伤的发展中起关键作用。因此，抗炎治疗是一种有潜在前景的ICH治疗方法。最近，发现NLRP3炎性小体促进炎症反应。然而，ICH后NLRP3炎性小体的作用尚未得到充分研究。为了探索NLRP3炎性小体的潜力，我们在体外和体内检测了NLRP3表达、炎症、脑水肿和神经功能。我们发现ICH激活了NLRP3炎性小体和炎症。然而，NLRP3 RNA干扰可减轻ICH后的炎症和脑损伤。因此，这些发现表明，编码NLRP3 RNA干扰的重组腺病毒作为ICH抗炎治疗的潜在策略可能具有价值。
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