Feng Li, Lin Xiao-Fang, Wan Zhi-Hua, Hu Dan, Du Yu-Kai
a School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , The People's Republic of China.
Gynecol Endocrinol. 2015;31(11):833-9. doi: 10.3109/09513590.2015.1041906. Epub 2015 Oct 6.
To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS).
MEDLINE and ScienceDirect were searched to retrieve relevant trials. The endpoint was the incidence of complications of pregnancy, gestational diabetes mellitus (GDM), pre-eclampsia (PE), miscarriage and premature birth included.
Five studies with 502 PCOS patients with metformin administration throughout pregnancy and 427 controls who used metformin just to get conception were included in our meta-analysis. In study group, a significantly lower change of emerging miscarriage and premature birth was observed, the pooled relative risk (RR) was 0.32 (95% confidence interval (CI): 0.19-0.56) for miscarriage and 0.40 (95%CI: 0.18-0.91) for premature birth. No significant difference was demonstrated in emerging GDM and PE.
Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects.
评估孕期全程使用二甲双胍对多囊卵巢综合征（PCOS）女性妊娠相关并发症的疗效。
检索MEDLINE和ScienceDirect以获取相关试验。终点指标为妊娠并发症、妊娠期糖尿病（GDM）、先兆子痫（PE）、流产和早产的发生率。
五项研究纳入了502例孕期全程使用二甲双胍的PCOS患者以及427例仅在受孕时使用二甲双胍的对照者。在研究组中，流产和早产的发生率显著降低，流产的合并相对风险（RR）为0.32（95%置信区间（CI）：0.19 - 0.56），早产的RR为0.40（95%CI：0.18 - 0.91）。在GDM和PE的发生率方面未显示出显著差异。
孕期全程使用二甲双胍可降低PCOS患者流产和早产的RR，且无严重副作用。
