Institute of Plant Sciences Paris-Saclay (IPS2), University Paris-sud 11, 91405 Orsay, France.
Institute of interdisciplinary Scientific Research, Jianghan University, 430056, Wuhan, China.
Trends Plant Sci. 2015 Oct;20(10):614-621. doi: 10.1016/j.tplants.2015.07.005.
Histone lysine acetylation is well known for being important in the epigenetic regulation of gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated proteins involved in important metabolic pathways, such as photosynthesis and respiration in plants. Enzymes involved in histone acetylation and deacetylation are being identified as regulators of acetylation of metabolic enzymes. Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC). Further research is required to determine whether and how HATs and HDACs sense cellular metabolite signals to control gene expression and metabolic enzyme activity through lysine acetylation and deacetylation.
组蛋白赖氨酸乙酰化在真核细胞中基因表达的表观遗传调控中起着重要作用，这是众所周知的。最近的研究揭示了大量参与重要代谢途径的乙酰化蛋白，如植物中的光合作用和呼吸作用。参与组蛋白乙酰化和去乙酰化的酶被确定为代谢酶乙酰化的调节剂。重要的是，关键代谢物，如乙酰辅酶 A 和 NAD(+)，参与蛋白质乙酰化和去乙酰化过程，它们的细胞水平可能调节组蛋白乙酰转移酶 (HAT) 和去乙酰化酶 (HDAC) 的活性。需要进一步的研究来确定 HAT 和 HDAC 是否以及如何感知细胞代谢物信号，通过赖氨酸乙酰化和去乙酰化来控制基因表达和代谢酶活性。
