胆固醇肉芽肿：病例系列及文献综述
Cholesterol granuloma: a case series & review of literature.
作者信息
Shrirao Neha, Mukherjee Bipasha, Krishnakumar S, Biswas Jyotirmay
机构信息
Orbit, Oculoplasty, Reconstructive & Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, 18, College Road, Chennai, 600 006, India.
Ophthalmic Pathology, Sankara Nethralaya, Medical Research Foundation, Chennai, India.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):185-8. doi: 10.1007/s00417-015-3178-9. Epub 2015 Oct 6.
BACKGROUND
Cholesterol granuloma (CG) is a foreign body reaction to crystallized cholesterol. Orbitofrontal CG is a rare entity with few cases reported in literature. It is usually seen in young to middle-aged males with a history of trauma. Computed tomography features include hypodense lesion-causing bone erosion. CG has typical histopathological features with cholesterol clefts, multinucleated giant cells, histiocytes, foamy macrophages, and altered blood pigments. Management is by total excision of the lesion with curettage of the underlying bone to prevent recurrence.
MATERIAL & METHOD: We present an interventional case series of five patients of orbitofrontal CG, two of them females.
RESULT
None of the patients gave a history of trauma. Management was by excision of the lesion and curettage confirmed with a 30° rigid endoscope.
CONCLUSION
Cholesterol granulomas can present as superior orbital mass lesions in the absence of trauma.
背景
胆固醇肉芽肿（CG）是对结晶胆固醇的异物反应。眶额部胆固醇肉芽肿是一种罕见的疾病，文献报道的病例较少。它通常见于有外伤史的青年至中年男性。计算机断层扫描特征包括导致骨质侵蚀的低密度病变。胆固醇肉芽肿具有典型的组织病理学特征，包括胆固醇裂隙、多核巨细胞、组织细胞、泡沫巨噬细胞和改变的血色素。治疗方法是彻底切除病变并刮除下方的骨质以防止复发。
材料与方法
我们展示了一组5例眶额部胆固醇肉芽肿患者的介入病例系列，其中2例为女性。
结果
所有患者均无外伤史。治疗方法是切除病变，并通过30°硬性内窥镜确认刮除。
结论
胆固醇肉芽肿可在无外伤的情况下表现为眶上部肿块病变。
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