Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Cell Metab. 2015 Oct 6;22(4):540-1. doi: 10.1016/j.cmet.2015.09.021.
Hunger increases physical activity and stamina to support food-directed foraging behaviors, but underlying mechanisms are unclear. In this issue, Fernandes et al. (2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.
饥饿会增加身体活动和耐力，以支持以食物为导向的觅食行为，但潜在的机制尚不清楚。在本期杂志中，Fernandes 等人（2015）表明，破坏中脑多巴胺神经元中瘦素调节的 STAT3 信号会增加小鼠跑步的奖励效应，这可以解释耐力跑者所体验到的“快感”。
