棕色脂肪和米色脂肪：产热之外的生理作用
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
作者信息
Kajimura Shingo, Spiegelman Bruce M, Seale Patrick
机构信息
UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143-0669, USA.
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Metab. 2015 Oct 6;22(4):546-59. doi: 10.1016/j.cmet.2015.09.007.
Abstract
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.
摘要
由于棕色脂肪组织（BAT）通过解偶联蛋白1（UCP1）消耗能量，BAT作为肥胖症和包括2型糖尿病在内的代谢性疾病的一种治疗干预手段已受到关注。随着我们对经典棕色和米色脂肪细胞的生理作用有了更深入的了解，越来越清楚的是，BAT不仅仅是一个产热器官。对各种外部/内部信号作出反应而增加的米色脂肪量与葡萄糖和脂质稳态的显著改善有关，而这可能并非完全由UCP1介导。我们旨在讨论关于棕色和米色脂肪细胞的发育谱系、分子调控及新功能的最新见解。
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