Alfano Lindsay N, Lowes Linda P
Nationwide Children's Hospital, Center for Gene Therapy, Columbus, OH, USA.
Ther Clin Risk Manag. 2015 Sep 25;11:1459-67. doi: 10.2147/TCRM.S65368. eCollection 2015.
Sporadic inclusion body myositis is the most common inflammatory muscle disorder preferentially affecting males over the age of 40 years. Progressive muscle weakness of the finger flexors and quadriceps muscles results in loss of independence with activities of daily living and eventual wheelchair dependence. Initial signs of disease are often overlooked and can lead to mis- or delayed diagnosis. The underlying cause of disease is unknown, and disease progression appears refractory to available treatment options. This review discusses the clinical presentation of inclusion body myositis and the current efforts in diagnosis, and focuses on the current state of research for both nonpharmacological and pharmacological treatment options for this patient group.
散发性包涵体肌炎是最常见的炎性肌肉疾病，好发于40岁以上男性。手指屈肌和股四头肌进行性肌无力导致日常生活活动能力丧失，最终依赖轮椅。疾病的初始症状常被忽视，可导致误诊或诊断延迟。疾病的根本原因尚不清楚，而且疾病进展似乎对现有的治疗方法无效。本文综述了包涵体肌炎的临床表现及目前的诊断方法，并重点介绍了针对该患者群体的非药物和药物治疗方案的研究现状。
