Chen Yu-Guang, Lin Te-Yu, Dai Ming-Shen, Lin Cheng-Li, Hung Yuan, Huang Wen-Sheng, Kao Chia-Hung
From the Division of Hematology/Oncology (Y-GC, M-SD), Division of Infectious Diseases and Tropical Medicine(T-YL), Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei (YH), Management Office for Health Data (C-LL), College of Medicine, China Medical University, Taichung (C-LL), Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, (W-SH), Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK).
Medicine (Baltimore). 2015 Oct;94(40):e1608. doi: 10.1097/MD.0000000000001608.
Carbon monoxide (CO) poisoning can cause several life-threatening complications, particularly in cardiovascular and neurological systems. However, no studies have been performed to investigate the association between peripheral artery disease (PAD) and CO poisoning. We constructed a population-based retrospective cohort study to clarify the risks between PAD and CO poisoning. This population-based cohort study involved analyzing data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database, with a follow-up period extending to the end of 2011. We identified patients with CO poisoning and selected a comparison cohort that was frequency matched according to age, sex, and year of diagnosis of CO poisoning at a ratio of 1 patient to 4 control patients. We analyzed the risks for patients with CO poisoning and PAD by using Cox proportional hazards regression models. In this study, 9046 patients with CO poisoning and 36,183 controls were included. The overall risks for developing PAD were 1.85-fold in the patients with CO poisoning compared with the comparison cohort after adjusting for age, sex, and comorbidities. Our long-term cohort study results showed a higher risk for PAD development among patients with CO poisoning.
一氧化碳（CO）中毒可引发多种危及生命的并发症，尤其是在心血管和神经系统方面。然而，尚未有研究探讨外周动脉疾病（PAD）与CO中毒之间的关联。我们开展了一项基于人群的回顾性队列研究，以阐明PAD与CO中毒之间的风险关系。这项基于人群的队列研究涉及分析1998年至2010年从台湾国民健康保险研究数据库获取的数据，随访期延长至2011年底。我们确定了CO中毒患者，并根据年龄、性别和CO中毒诊断年份，以1例患者对应4例对照患者的比例，选取了频率匹配的对照队列。我们使用Cox比例风险回归模型分析了CO中毒合并PAD患者的风险。本研究纳入了9046例CO中毒患者和36183例对照。在调整年龄、性别和合并症后，CO中毒患者发生PAD的总体风险是对照队列的1.85倍。我们的长期队列研究结果显示，CO中毒患者发生PAD的风险更高。
