循环半乳糖凝集素-1和90K/Mac-2BP与结直肠癌患者的肿瘤分期相关。
Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer.
作者信息
Wu Keng-Liang, Chen Hong-Hwa, Pen Chen-Tzi, Yeh Wen-Ling, Huang Eng-Yen, Hsiao Chang-Chun, Yang Kuender D
机构信息
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan ; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.
Division of Colonic and Rectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan ; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
出版信息
Biomed Res Int. 2015;2015:306964. doi: 10.1155/2015/306964. Epub 2015 Sep 13.
BACKGROUND
The simultaneous correlation of serum galectin-1, galectin-3, and 90K/Mac-2BP levels with clinical stages of patients with colorectal cancer has not yet been clarified. We plan to measure the serum levels of galectin-1, galectin-3, and 90K/Mac-2BP of patients at different stages of colorectal cancer and analyze the correlation of these galectins with stages of colorectal cancers.
METHODS
198 colorectal cancer patients (62 ± 13 (range 31-85) years old, 43.6% female) were recruited for this study. Subjects' blood samples were checked for serum galectin-1, galectin-3, 90K/Mac-2BP, and carcinoembryonic antigen by sandwich enzyme-linked immunosorbent assay. We determined the correlation between plasma concentrations with clinical tumor stages.
RESULTS
Colorectal cancer patients with larger cancer sizes (stages T3, T4 rather than T1, T2) have higher serum 90K/Mac-2BP (P = 0.014) and patients with lymph node metastasis have higher serum galectin-1 (P = 0.002) but there was not a significant correlation between galectin-3 and tumor staging of colon cancer. In colorectal cancer patients even with normal carcinoembryonic antigen, serum galectin-1 could predict more lymph node metastasis.
CONCLUSIONS
We found 90K/Mac-2BP correlated with the size of colorectal cancer. Galectin-1 but not galectin-3 was associated with lymph node metastasis. Galectin-1 could predict more lymph node metastasis in colorectal cancer patients with normal serum carcinoembryonic antigen.
背景
血清半乳糖凝集素-1、半乳糖凝集素-3和90K/Mac-2BP水平与结直肠癌患者临床分期的同时相关性尚未明确。我们计划测量不同阶段结直肠癌患者血清半乳糖凝集素-1、半乳糖凝集素-3和90K/Mac-2BP的水平，并分析这些半乳糖凝集素与结直肠癌分期的相关性。
方法
本研究招募了198例结直肠癌患者（年龄62±13岁（范围31 - 85岁），女性占43.6%）。通过夹心酶联免疫吸附测定法检测受试者血样中的血清半乳糖凝集素-1、半乳糖凝集素-3、90K/Mac-2BP和癌胚抗原。我们确定了血浆浓度与临床肿瘤分期之间的相关性。
结果
肿瘤体积较大的结直肠癌患者（T3、T4期而非T1、T2期）血清90K/Mac-2BP水平较高（P = 0.014），有淋巴结转移的患者血清半乳糖凝集素-1水平较高（P = 0.002），但半乳糖凝集素-3与结肠癌肿瘤分期之间无显著相关性。在癌胚抗原正常的结直肠癌患者中，血清半乳糖凝集素-1可预测更多的淋巴结转移。
结论
我们发现90K/Mac-2BP与结直肠癌的大小相关。半乳糖凝集素-1而非半乳糖凝集素-3与淋巴结转移有关。在血清癌胚抗原正常的结直肠癌患者中，半乳糖凝集素-1可预测更多的淋巴结转移。
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