Storman Monika, Przybyłkowski Adam, Czupryniak Leszek
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1a, 02-304 Warsaw, Poland.
Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Banacha 1a, 02-304 Warsaw, Poland.
Int J Mol Sci. 2025 Aug 8;26(16):7662. doi: 10.3390/ijms26167662.
Galectin-3 (Gal-3) secreted by activated macrophages is involved in inflammation, fibrosis, and tumorigenesis. It is considered a potential biomarker and therapeutic target. This study assessed the association between serum Gal-3, type 2 diabetes (T2D), and colorectal polyps (CRPs). In this cross-sectional study, 80 non-cancer patients undergoing colonoscopy were divided into four subgroups based on T2D and CRP status. Serum Gal-3 and metabolic parameters were measured. All patients' mean serum Gal-3 level was 13.63 ng/mL. Gal-3 levels were significantly higher in T2D+ than in the T2D- group (14.93 ng/mL, = 0.02). Gal-3 concentration correlated significantly with age (rho = 0.281; = 0.012), gender (rho = 0.220; = 0.049), serum peptide C levels (rho = 0.957; = 0.006), and serum IGF-1 levels (rho = -0.417; < 0.001) in all patients, and for patients T2D-, it also correlated significantly with fasting plasma glucose levels (rho = -0.406; = 0.009). A logistic regression analysis of the risk of polyps was conducted (CRP+ vs. CRP-) considering factors such as gender, age, body weight, waist circumference, T2D, HOMA-IR, insulin, API, IGF-1, total cholesterol, and Gal-3. Gal-3 serum was shown to be a strong independent predictor of CRPs regardless of the presence of T2D+ ( = 0.031). Gal-3 may correlate with the development of CRPs and might be a candidate biomarker of CRPs/cancer development.
活化巨噬细胞分泌的半乳糖凝集素-3（Gal-3）参与炎症、纤维化和肿瘤发生过程。它被认为是一种潜在的生物标志物和治疗靶点。本研究评估了血清Gal-3、2型糖尿病（T2D）和结直肠息肉（CRP）之间的关联。在这项横断面研究中，80名接受结肠镜检查的非癌症患者根据T2D和CRP状态分为四个亚组。测量了血清Gal-3和代谢参数。所有患者的血清Gal-3平均水平为13.63 ng/mL。T2D+组的Gal-3水平显著高于T2D-组（14.93 ng/mL，P = 0.02）。在所有患者中，Gal-3浓度与年龄（rho = 0.281；P = 0.012）、性别（rho = 0.220；P = 0.049）、血清肽C水平（rho = 0.957；P = 0.006）和血清IGF-1水平（rho = -0.417；P < 0.001）显著相关，对于T2D-患者，它还与空腹血糖水平显著相关（rho = -0.406；P = 0.009）。考虑性别、年龄、体重、腰围、T2D、HOMA-IR、胰岛素、API、IGF-1、总胆固醇和Gal-3等因素，对息肉风险进行了逻辑回归分析。无论是否存在T2D+，血清Gal-3均被证明是CRP的强有力独立预测因子（P = 0.031）。Gal-3可能与CRP的发生相关，可能是CRP/癌症发生的候选生物标志物。
