首发精神分裂症患者及其同胞面部情绪识别与执行功能之间的关系。
The relationship between facial emotion recognition and executive functions in first-episode patients with schizophrenia and their siblings.
作者信息
Yang Chengqing, Zhang Tianhong, Li Zezhi, Heeramun-Aubeeluck Anisha, Liu Na, Huang Nan, Zhang Jie, He Leiying, Li Hui, Tang Yingying, Chen Fazhan, Liu Fei, Wang Jijun, Lu Zheng
机构信息
Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China.
Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Road, Shanghai, 200127, China.
出版信息
BMC Psychiatry. 2015 Oct 8;15:241. doi: 10.1186/s12888-015-0618-3.
BACKGROUND
Although many studies have examined executive functions and facial emotion recognition in people with schizophrenia, few of them focused on the correlation between them. Furthermore, their relationship in the siblings of patients also remains unclear. The aim of the present study is to examine the correlation between executive functions and facial emotion recognition in patients with first-episode schizophrenia and their siblings.
METHODS
Thirty patients with first-episode schizophrenia, their twenty-six siblings, and thirty healthy controls were enrolled. They completed facial emotion recognition tasks using the Ekman Standard Faces Database, and executive functioning was measured by Wisconsin Card Sorting Test (WCST). Hierarchical regression analysis was applied to assess the correlation between executive functions and facial emotion recognition.
RESULTS
Our study found that in siblings, the accuracy in recognizing low degree 'disgust' emotion was negatively correlated with the total correct rate in WCST (r = -0.614, p = 0.023), but was positively correlated with the total error in WCST (r = 0.623, p = 0.020); the accuracy in recognizing 'neutral' emotion was positively correlated with the total error rate in WCST (r = 0.683, p = 0.014) while negatively correlated with the total correct rate in WCST (r = -0.677, p = 0.017). People with schizophrenia showed an impairment in facial emotion recognition when identifying moderate 'happy' facial emotion, the accuracy of which was significantly correlated with the number of completed categories of WCST (R(2) = 0.432, P < .05). There were no correlations between executive functions and facial emotion recognition in the healthy control group.
CONCLUSIONS
Our study demonstrated that facial emotion recognition impairment correlated with executive function impairment in people with schizophrenia and their unaffected siblings but not in healthy controls.
背景
尽管许多研究已经考察了精神分裂症患者的执行功能和面部情绪识别，但其中很少有研究关注它们之间的相关性。此外，它们在患者兄弟姐妹中的关系也仍不明确。本研究的目的是考察首发精神分裂症患者及其兄弟姐妹的执行功能与面部情绪识别之间的相关性。
方法
招募了30名首发精神分裂症患者、他们的26名兄弟姐妹以及30名健康对照者。他们使用艾克曼标准面孔数据库完成面部情绪识别任务，并通过威斯康星卡片分类测验（WCST）测量执行功能。应用分层回归分析来评估执行功能与面部情绪识别之间的相关性。
结果
我们的研究发现，在兄弟姐妹中，识别低度“厌恶”情绪的准确性与WCST的总正确率呈负相关（r = -0.614，p = 0.023），但与WCST的总错误数呈正相关（r = 0.623，p = 0.020）；识别“中性”情绪的准确性与WCST的总错误率呈正相关（r = 0.683，p = 0.014），而与WCST的总正确率呈负相关（r = -0.677，p = 0.017）。精神分裂症患者在识别中度“快乐”面部情绪时表现出面部情绪识别受损，其准确性与WCST完成的类别数显著相关（R(2) = 0.432，P < 0.05）。健康对照组的执行功能与面部情绪识别之间没有相关性。
结论
我们的研究表明，面部情绪识别受损与精神分裂症患者及其未患病的兄弟姐妹的执行功能受损相关，但与健康对照组无关。
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