《神经性厌食症少女左心室大小和心功能的超声心动图研究》
An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa.
机构信息
Children's Heart Centre, British Columbia Children's Hospital, Canada.
Division of Adolescent Medicine and Provincial Specialized Eating Disorders Program, British Columbia Children's Hospital, Canada.
出版信息
Eur Eat Disord Rev. 2016 Jan;24(1):26-33. doi: 10.1002/erv.2409. Epub 2015 Oct 8.
OBJECTIVE
This retrospective case-control study investigated cardiac dimensions and ventricular function in female adolescents with anorexia nervosa (AN) compared with controls.
METHODS
Echocardiographic measurements of left ventricular (LV) dimensions, LV mass index, left atrial size and cardiac index were made. Detailed measures of systolic and diastolic ventricular function were made including tissue Doppler imaging. Patients were stratified by body mass index ≤10th percentile (AN ≤ 10th) and >10th percentile (AN > 10th).
RESULTS
Ninety-five AN patients and 58 controls were included. AN and AN ≤ 10th groups had reduced LV dimensions, LV mass index, left atrial size and cardiac index compared with controls. There were no differences between groups in measures of systolic function. Measures of diastolic tissue Doppler imaging were decreased in AN and AN ≤ 10th. No differences in echocardiographic measurements existed between controls and AN > 10th.
DISCUSSION
Female adolescents with AN have preserved systolic function and abnormalities of diastolic ventricular function. AN ≤ 10th may be a higher risk group.
目的
本回顾性病例对照研究旨在比较厌食症（AN）女性青少年与对照组的心脏结构和心室功能。
方法
进行了左心室（LV）尺寸、LV 质量指数、左心房大小和心指数的超声心动图测量。还进行了包括组织多普勒成像在内的收缩和舒张心室功能的详细测量。根据体重指数（BMI）≤第 10 百分位数（AN≤第 10）和＞第 10 百分位数（AN＞第 10）对患者进行分层。
结果
纳入了 95 名 AN 患者和 58 名对照组。与对照组相比，AN 和 AN≤第 10 组的 LV 尺寸、LV 质量指数、左心房大小和心指数均降低。各组之间的收缩功能测量值无差异。AN 和 AN≤第 10 组的舒张组织多普勒成像测量值降低。对照组和 AN＞第 10 组之间的超声心动图测量值无差异。
讨论
患有 AN 的女性青少年的收缩功能正常，但舒张心室功能异常。AN≤第 10 可能是一个更高风险的群体。
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