关于啮齿动物着床的思考。

Reflections on Rodent Implantation.

作者信息

Cha Jeeyeon M, Dey Sudhansu K

机构信息

Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229-3039, USA.

出版信息

Adv Anat Embryol Cell Biol. 2015;216:69-85. doi: 10.1007/978-3-319-15856-3_5.

DOI:10.1007/978-3-319-15856-3_5

PMID:26450495

Abstract

Embryo implantation is a complex process involving endocrine, paracrine, autocrine, and juxtacrine modulators that span cell-cell and cell-matrix interactions. The quality of implantation is predictive for pregnancy success. Earlier observational studies formed the basis for genetic and molecular approaches that ensued with emerging technological advances. However, the precise sequence and details of the molecular interactions involved have yet to be defined. This review reflects briefly on aspects of our current understanding of rodent implantation as a tribute to Roger Short's lifelong contributions to the field of reproductive physiology.

摘要

胚胎着床是一个复杂的过程，涉及内分泌、旁分泌、自分泌和邻分泌调节因子，涵盖细胞间和细胞与基质间的相互作用。着床质量可预测妊娠成功与否。早期的观察性研究为随后随着技术进步而出现的遗传和分子方法奠定了基础。然而，所涉及的分子相互作用的确切顺序和细节尚未明确。本综述简要回顾了我们目前对啮齿动物着床的理解，以致敬罗杰·肖特对生殖生理学领域的毕生贡献。