Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA.
Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA.
Trends Endocrinol Metab. 2018 Jul;29(7):481-491. doi: 10.1016/j.tem.2018.04.001. Epub 2018 Apr 25.
Progesterone acts through the progesterone receptor to direct physiological adaption of the uterus in preparation and completion of pregnancy. Genome-wide transcriptome and cistrome analyses have uncovered new members and novel modifiers of the progesterone signaling pathway. Genetically engineered mice allow functional assessment of newly identified genes in vivo and provide insights on the impact of progesterone receptor-dependent molecular mechanisms on pregnancy at the organ system level. Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity. This review discusses recent advances on the discovery of the progesterone receptor network, with special focus on the endometrium at early pregnancy and myometrium during parturition.
孕酮通过孕酮受体发挥作用，指导子宫的生理适应，为妊娠做好准备并完成妊娠。全基因组转录组和顺式作用元件分析揭示了孕酮信号通路的新成员和新调节剂。基因工程小鼠允许在体内对新鉴定的基因进行功能评估，并提供关于孕酮受体依赖性分子机制对器官系统水平妊娠的影响的见解。孕酮受体异构体通过其独特和共同的下游靶基因共同介导孕酮信号，这使得异构体的比例在修饰孕酮活性方面具有重要意义。本文综述了孕酮受体网络发现的最新进展，特别关注妊娠早期的子宫内膜和分娩期间的子宫肌层。
