一只金毛猎犬脑部出现的罕见脂肪瘤肿块。

An unusual lipomatous brain mass in a Golden Retriever dog.

作者信息

Scott Steven J, Elliot Kirsty, Philibert Helene, Summers Brian A, Godson Dale, Singh Baljit, Simko Elemir

机构信息

Prairie Diagnostic Services Inc., Saskatoon, Saskatchewan, Canada (Godson)Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada (Scott, Elliot, Philibert, Singh, Simko)True North Veterinary Diagnostics Inc., Langley, British Columbia, Canada (Scott)University of Melbourne, Melbourne, Australia (Summers)

出版信息

J Vet Diagn Invest. 2015 Nov;27(6):772-6. doi: 10.1177/1040638715608216. Epub 2015 Oct 8.

DOI:10.1177/1040638715608216

PMID:26450836

Abstract

A 9-year-old Golden Retriever dog was presented to the Veterinary Medical Center with a 3-week history of grand mal seizures and was subsequently euthanized. At autopsy, a discrete, firm, expansile mass was found in the right pyriform lobe, which compressed the ipsilateral hippocampus, thalamus, and cerebral cortex. Histologically, the mass was composed of well-differentiated adipose tissue supported by fibrous and mucinous stroma. Adipocytes exhibited strong immunoreactivity for vimentin and were negative for pancytokeratin (AE1/AE3), glial fibrillary acidic protein, neuron-specific enolase, and synaptophysin. These findings are most compatible with an intracranial lipomatous hamartoma, which is an extraparenchymal lesion that has been identified in several species. The current report describes an intracerebral lipomatous hamartoma in a veterinary species.

摘要

一只9岁的金毛猎犬因有3周的癫痫大发作病史被送至兽医医疗中心，随后实施了安乐死。尸检时，在右侧梨状叶发现一个离散、坚实、有扩展性的肿块，该肿块压迫同侧海马体、丘脑和大脑皮层。组织学上，肿块由纤维性和黏液性基质支持的分化良好的脂肪组织组成。脂肪细胞对波形蛋白呈强免疫反应性，而对全细胞角蛋白（AE1/AE3）、胶质纤维酸性蛋白、神经元特异性烯醇化酶和突触素呈阴性。这些发现与颅内脂肪瘤样错构瘤最为相符，颅内脂肪瘤样错构瘤是一种已在多个物种中发现的脑实质外病变。本报告描述了一例兽医物种中的脑内脂肪瘤样错构瘤。