脂肪生成受到热休克蛋白90（Hsp90）和高分子量亲免素FKBP51的监测。
Adipogenesis is under surveillance of Hsp90 and the high molecular weight Immunophilin FKBP51.
作者信息
Toneatto Judith, Charó Nancy L, Galigniana Natalia M, Piwien-Pilipuk Graciela
机构信息
Laboratory of Nuclear Architecture; Instituto de Biología y Medicina Experimental - CONICET ; Buenos Aires, Argentina.
出版信息
Adipocyte. 2015 May 13;4(4):239-47. doi: 10.1080/21623945.2015.1049401. eCollection 2015 Oct-Dec.
Adipose tissue plays a central role in the control of energy balance as well as in the maintenance of metabolic homeostasis. It was not until recently that the first evidences of the role of heat shock protein (Hsp) 90 and high molecular weight immunophilin FKBP51 have been described in the process of adipocyte differentiation. Recent reports describe their role in the regulation of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the architecture of the nucleus through its participation in the reorganization of the nuclear lamina. Therefore, the aim of this review is to integrate and discuss the recent advances in the field, with special emphasis on the roles of Hsp90 and FKBP51 in the process of adipocyte differentiation.
脂肪组织在能量平衡的控制以及代谢稳态的维持中起着核心作用。直到最近，才有关于热休克蛋白（Hsp）90和高分子量亲免素FKBP51在脂肪细胞分化过程中作用的首批证据被描述。最近的报道阐述了它们在过氧化物酶体增殖物激活受体γ（PPARγ）调控中的作用，PPARγ是控制脂肪生成和维持脂肪细胞表型的关键转录因子。此外，通过参与核纤层的重组，FKBP51在细胞核结构组织中还发现了新的作用。因此，本综述的目的是整合并讨论该领域的最新进展，特别强调Hsp90和FKBP51在脂肪细胞分化过程中的作用。
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