生酮饮食对DBA/2小鼠听觉门控的影响：一项概念验证研究。
Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study.
作者信息
Tregellas Jason R, Smucny Jason, Legget Kristina T, Stevens Karen E
机构信息
Research Service, Denver VA Medical Center, Denver, CO, USA; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
出版信息
Schizophr Res. 2015 Dec;169(1-3):351-354. doi: 10.1016/j.schres.2015.09.022. Epub 2015 Oct 9.
Although the ketogenic diet has shown promise in a pilot study and case report in schizophrenia, its effects in animal models of hypothesized disease mechanisms are unknown. This study examined effects of treatment with the ketogenic diet on hippocampal P20/N40 gating in DBA/2 mice, a translational endophenotype that mirrors inhibitory deficits in P50 sensory gating in schizophrenia patients. As expected, the diet increased blood ketone levels. Animals with the highest ketone levels showed the lowest P20/N40 gating ratios. These preliminary results suggest that the ketogenic diet may effectively target sensory gating deficits and is a promising area for additional research in schizophrenia.
尽管生酮饮食在一项针对精神分裂症的初步研究和病例报告中显示出了前景，但其在假设疾病机制的动物模型中的作用尚不清楚。本研究检测了生酮饮食治疗对DBA/2小鼠海马体P20/N40门控的影响，这是一种转化型内表型，反映了精神分裂症患者P50感觉门控的抑制缺陷。正如预期的那样，这种饮食提高了血液中的酮水平。酮水平最高的动物表现出最低的P20/N40门控比率。这些初步结果表明，生酮饮食可能有效地针对感觉门控缺陷，是精神分裂症进一步研究的一个有前景的领域。
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