抗癫痫药物左乙拉西坦可改善DBA/2小鼠的听觉门控。
The antiepileptic drug levetiracetam improves auditory gating in DBA/2 mice.
作者信息
Smucny Jason, Stevens Karen E, Tregellas Jason R
机构信息
Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA ; Research Service, Denver VA Medical Center, Denver, CO, USA ; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
出版信息
NPJ Schizophr. 2015;1:15002-. doi: 10.1038/npjschz.2015.2.
Schizophrenia is associated with deficits in P50 gating. This deficit is preclinically modeled in the DBA/2 mouse by depth recordings in the hippocampus. Neurobiologically, the deficit may be due to dysfunction in inhibitory circuitry. It follows that anti-epileptic drugs which impact this circuitry, such as levetiracetam (LEV), may improve gating. To that end, the goal of this study was to evaluate the ability of LEV to normalize sensory gating in the DBA/2 mouse. Gating of the murine analog of the P50, the P20-N40, was evaluated from hippocampal recordings in 39 male DBA/2 mice. Gating effects were evaluated using four doses of LEV (3, 10, 30, and 100 mg/kg). The 10 mg/kg dose improved P20-N40 gating ( = 0.016). No other doses significantly affected gating. Low-dose LEV may improve P20-N40 gating in the DBA/2 mouse model of schizophrenia. Low-doses of LEV may improve P20-N40 gating in the DBA/2 mouse model of schizophrenia and warrant further investigation in the illness.
精神分裂症与P50门控缺陷有关。这种缺陷在临床前通过在DBA/2小鼠海马体中的深度记录进行模拟。从神经生物学角度来看，这种缺陷可能是由于抑制性神经回路功能障碍所致。因此，影响该神经回路的抗癫痫药物，如左乙拉西坦（LEV），可能会改善门控功能。为此，本研究的目的是评估LEV使DBA/2小鼠感觉门控正常化的能力。通过对39只雄性DBA/2小鼠海马体记录评估小鼠P50类似物P20 - N40的门控情况。使用四种剂量的LEV（3、10、30和100mg/kg）评估门控效果。10mg/kg剂量改善了P20 - N40门控（P = 0.016）。其他剂量均未对门控产生显著影响。低剂量LEV可能改善精神分裂症DBA/2小鼠模型中的P20 - N40门控。低剂量LEV可能改善精神分裂症DBA/2小鼠模型中的P20 - N40门控，值得对该疾病进行进一步研究。
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