Bhattarai Janardhan Prasad, Park Soo Joung, Chun Sang Woo, Cho Dong Hyu, Han Seong Kyu
Department of Oral Physiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Department of Oral Physiology, College of Dentistry, Institute of Wonkwang Biomaterial and Implant, Wonkwang University, 344-2 Shinyong Dong, Iksan 570-749, Republic of Korea.
Neurosci Lett. 2015 Nov 3;608:51-6. doi: 10.1016/j.neulet.2015.10.012. Epub 2015 Oct 28.
Taurine is an essential amino-sulfonic acid having a fundamental function in the brain, participating in both cell volume regulation and neurotransmission. Using a whole cell voltage patch clamp technique, the taurine-activated neurotransmitter receptors in the preoptic hypothalamic area (PHA) neurons were investigated. In the first set of experiments, different concentrations of taurine were applied on PHA neurons. Taurine-induced responses were concentration-dependent. Taurine-induced currents were action potential-independent and sensitive to strychnine, suggesting the involvement of glycine receptors. In addition, taurine activated not only α-homomeric, but also αβ-heteromeric glycine receptors in PHA neurons. Interestingly, a low concentration of taurine (0.5mM) activated glycine receptors, whereas a higher concentration (3mM) activated both glycine and gamma-aminobutyric acid A (GABAA) receptors in PHA neurons. These results suggest that PHA neurons are influenced by taurine and respond via glycine and GABAA receptors.
牛磺酸是一种必需的氨基磺酸，在大脑中具有重要功能，参与细胞容积调节和神经传递。运用全细胞膜片钳技术，对下丘脑视前区（PHA）神经元中牛磺酸激活的神经递质受体进行了研究。在第一组实验中，将不同浓度的牛磺酸施加于PHA神经元。牛磺酸诱导的反应呈浓度依赖性。牛磺酸诱导的电流不依赖动作电位，且对士的宁敏感，提示甘氨酸受体参与其中。此外，牛磺酸不仅激活PHA神经元中的α同聚体，还激活αβ异聚体甘氨酸受体。有趣的是，低浓度的牛磺酸（0.5 mM）激活甘氨酸受体，而高浓度（3 mM）则激活PHA神经元中的甘氨酸和γ-氨基丁酸A（GABAA）受体。这些结果表明，PHA神经元受牛磺酸影响，并通过甘氨酸和GABAA受体作出反应。
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