通过声化学方法合成多功能牛血清白蛋白微胶囊用于靶向给药和控释。
Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release.
作者信息
Li Zhanfeng, Xu Fengzhi, Li Quanshun, Liu Songfeng, Wang Hongyan, Möhwald Helmuth, Cui Xuejun
机构信息
College of Chemistry, Jilin University, Changchun 130012, China.
College of Life Sciences, Jilin University, Changchun 130012, China.
出版信息
Colloids Surf B Biointerfaces. 2015 Dec 1;136:470-8. doi: 10.1016/j.colsurfb.2015.09.056. Epub 2015 Oct 1.
Multifunctional folic acid conjugated BSA@Fe3O4 microcapsules (FA-BSA@Fe3O4 MCs) have been prepared successfully based on the sonochemical method. The as-synthesized FA-BSA@Fe3O4 MCs have a suitable size range for biomedical applications, and a high loading capacity for water-insoluble drugs. Furthermore, FA-BSA@Fe3O4 MCs show excellent magnetic properties. Cytotoxicity tests indicate that FA-BSA@Fe3O4 MCs are non-toxic. Cellular uptake and flow cytometric assay illustrate together that FA-BSA@Fe3O4 MCs can target tumor cells selectively through molecular targeted endocytosis. As carriers for water-insoluble drugs, FA-BSA@Fe3O4 MCs are also proved to possess superior redox- and thermo- dual responsiveness for controlled drug release.
基于声化学方法成功制备了多功能叶酸偶联的牛血清白蛋白@四氧化三铁微胶囊（FA-BSA@Fe3O4 MCs）。所合成的FA-BSA@Fe3O4 MCs具有适合生物医学应用的尺寸范围，以及对水不溶性药物的高负载能力。此外，FA-BSA@Fe3O4 MCs表现出优异的磁性。细胞毒性测试表明FA-BSA@Fe3O4 MCs无毒。细胞摄取和流式细胞术分析共同表明，FA-BSA@Fe3O4 MCs可通过分子靶向内吞作用选择性地靶向肿瘤细胞。作为水不溶性药物的载体，FA-BSA@Fe3O4 MCs也被证明具有优异的氧化还原和热双响应性以实现药物的控释。
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