Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Department of Preventive Medicine and Public Health, University of Zaragoza, Spain.
Psychiatry Res. 2015 Dec 15;230(2):377-82. doi: 10.1016/j.psychres.2015.09.022. Epub 2015 Sep 14.
Previous studies have generally found a relationship between negative and cognitive symptoms in schizophrenia. The present study investigated the relationship between the 5 PANSS factors of a recent consensus model developed by NIMH researchers, and cognitive performance as assessed with the MATRICS Consensus Cognitive Battery (MCCB) in 80 patients with schizophrenia using correlation and regression analyses. The PANSS Cognitive factor showed a small to moderate significant association with MCCB Speed of processing, Working memory, Verbal learning, the Neurocognitive composite score, and the Overall composite score. Notably, however, no relationship was found between the PANSS Negative factor and any of the MCCB scores. The Positive, Excited and Depressed factors also did not show associations with the MCCB. These results highlight the need for refined assessment instruments and support the relative independence of cognition from other domains of psychopathology, including negative symptoms, in patients with schizophrenia.
先前的研究普遍发现精神分裂症的阴性和认知症状之间存在关系。本研究使用相关性和回归分析，调查了美国国立精神卫生研究院（NIMH）研究人员最近提出的共识模型的 5 个 PANSS 因子与 80 名精神分裂症患者的认知表现（采用 MATRICS 共识认知成套测验，MCCB）之间的关系。PANSS 认知因子与 MCCB 的加工速度、工作记忆、词语学习、神经认知综合评分和总体综合评分呈中等程度的显著相关。然而，值得注意的是，PANSS 阴性因子与任何 MCCB 评分均无相关性。阳性、兴奋和抑郁因子也与 MCCB 无关联。这些结果强调了需要精细的评估工具，并支持认知与精神病理学的其他领域（包括阴性症状）相对独立，在精神分裂症患者中。
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