Sanders M R, Kostis J B, Frishman W H
Division of Cardiovascular Diseases and Hypertension, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick.
Med Clin North Am. 1989 Mar;73(2):283-314. doi: 10.1016/s0025-7125(16)30674-5.
This article reviews our current understanding of the physiology of myocardial contraction; recent research into its mechanical, macromolecular, and biochemical foundations; and its role in the clinical syndromes of congestive heart failure. This review serves as a background for discussing the mechanism of action and pharmacology of currently available and experimental inotropic agents. The clinical applications of these drugs are discussed and the successes and failures of the pharmacologic approach to patients with congestive heart failure analyzed.
本文回顾了我们目前对心肌收缩生理学的理解；对其机械、大分子和生化基础的最新研究；以及它在充血性心力衰竭临床综合征中的作用。这篇综述为讨论目前可用的和实验性的强心剂的作用机制和药理学提供了背景。文中讨论了这些药物的临床应用，并分析了药物治疗充血性心力衰竭患者的成败。
