杜氏肌营养不良症患儿的六分钟步行试验与两分钟步行试验：时间越长信息越多吗？
Six-minute walk test versus two-minute walk test in children with Duchenne muscular dystrophy: Is more time more information?
作者信息
Vill Katharina, Ille Lena, Schroeder Sebastian A, Blaschek Astrid, Müller-Felber Wolfgang
机构信息
Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
出版信息
Eur J Paediatr Neurol. 2015 Nov;19(6):640-6. doi: 10.1016/j.ejpn.2015.08.002. Epub 2015 Aug 20.
BACKGROUND/PURPOSE: The six minute walk test is a widely accepted primary outcome parameter in most studies in Duchenne muscular dystrophy (DMD). To compare information obtained by the six minute walk distance (6MWD) test and the two minute walk distance (2MWD) in patients with DMD, a cohort of 13 voluntary DMD boys did a repeated six minute walking test.
METHODS
Patients had to be ambulatory with a physical disability according to Levels 1-3 on the Vignos-Scale for lower extremity. Measurements were taken at one minute intervals. Reliability was measured by intraclass correlation.
RESULTS
Test-retest reliability for 6MWD and 2MWD in two different age classes was very good for both subgroups. Test-retest-reliability was lower in patients with more advanced disability in both tests. Walking speed remained completely stable from time points 1-6 minutes in the whole study patient collective, which indicates that physical exhaustion is not reached after six minutes even in more disabled patients.
CONCLUSION
Thus the 6MWD in DMD patients does not give additional information as compared to a 2MWD.
背景/目的：在大多数杜氏肌营养不良症（DMD）研究中，六分钟步行试验是一个广泛接受的主要结局参数。为了比较DMD患者通过六分钟步行距离（6MWD）试验和两分钟步行距离（2MWD）获得的信息，一组13名自愿参与的DMD男孩进行了重复的六分钟步行试验。
方法
根据下肢Vignos量表1-3级，患者必须能够行走但存在身体残疾。每隔一分钟进行测量。通过组内相关性测量可靠性。
结果
两个不同年龄组的6MWD和2MWD的重测信度在两个亚组中都非常好。在两项测试中，残疾程度较高的患者重测信度较低。在整个研究患者群体中，从第1至6分钟时间点步行速度保持完全稳定，这表明即使是残疾程度较高的患者在六分钟后也未达到身体疲劳。
结论
因此，与2MWD相比，DMD患者的6MWD并未提供额外信息。
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