寻求生育治疗的夫妇中，父亲尿液中邻苯二甲酸酯代谢物浓度与生殖结局之间的关联。
Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment.
作者信息
Dodge L E, Williams P L, Williams M A, Missmer S A, Souter I, Calafat A M, Hauser R
机构信息
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Reprod Toxicol. 2015 Dec;58:184-93. doi: 10.1016/j.reprotox.2015.09.007. Epub 2015 Oct 9.
INTRODUCTION
Limited evidence suggests that male exposure to ubiquitous environmental phthalates may result in poor reproductive outcomes among female partners.
METHODS
This analysis included male-female couples undergoing in vitro fertilization (IVF) and/or intrauterine insemination (IUI). We evaluated associations between the geometric mean of paternal specific gravity-adjusted urinary phthalate concentrations prior to the female partners' cycle and fertilization, embryo quality, implantation, and live birth using generalized linear mixed models.
RESULTS
Two-hundred eighteen couples underwent 211 IVF and 195 IUI cycles. Trends were observed between paternal urinary mono-3-carboxypropyl phthalate (MCPP; P=0.01) and mono(carboxyoctyl) phthalate (MCOP; P=0.01) and decreased odds of implantation. MCPP and MCOP were also associated with decreased odds of live birth following IVF (P=0.01 and P=0.04, respectively), and monobutyl phthalate above the first quartile was significantly associated with decreased odds of live birth following IUI (P=0.04). However, most urinary phthalate metabolites were not associated with these reproductive outcomes.
CONCLUSION
Selected phthalates were associated with decreased odds of implantation and live birth.
引言
有限的证据表明，男性接触普遍存在的环境邻苯二甲酸盐可能会导致女性伴侣的生殖结局不良。
方法
本分析纳入了接受体外受精（IVF）和/或宫腔内人工授精（IUI）的男女夫妇。我们使用广义线性混合模型评估了女性伴侣周期及受精前父亲特定重力校正尿邻苯二甲酸盐浓度的几何平均值与胚胎质量、着床和活产之间的关联。
结果
218对夫妇进行了211个IVF周期和195个IUI周期。观察到父亲尿中邻苯二甲酸单-3-羧丙酯（MCPP；P=0.01）和邻苯二甲酸单（羧基辛基）酯（MCOP；P=0.01）与着床几率降低之间存在趋势。MCPP和MCOP还与IVF后活产几率降低相关（分别为P=0.01和P=0.04），且邻苯二甲酸单丁酯高于第一四分位数与IUI后活产几率降低显著相关（P=0.04）。然而，大多数尿邻苯二甲酸代谢物与这些生殖结局无关。
结论
特定邻苯二甲酸盐与着床和活产几率降低相关。
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