治疗性低温能否降低足月围产期窒息新生儿的急性肾损伤？——一项随机对照试验。
Does therapeutic hypothermia reduce acute kidney injury among term neonates with perinatal asphyxia?--a randomized controlled trial.
作者信息
Tanigasalam Vasanthan, Bhat Vishnu, Adhisivam Bethou, Sridhar M G
机构信息
a Department of Neonatology and.
b Department of Biochemistry , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
出版信息
J Matern Fetal Neonatal Med. 2016;29(15):2545-8. doi: 10.3109/14767058.2015.1094785. Epub 2015 Oct 12.
OBJECTIVE
The objective of this study is to evaluate whether therapeutic hypothermia reduces the incidence of acute kidney injury (AKI) among term neonates perinatal asphyxia.
METHODS
This randomized controlled trial conducted in a tertiary care teaching hospital, south India included 120 term neonates with perinatal asphyxia who were randomized to receive either therapeutic hypothermia or standard supportive care. Renal parameters of neonates in both the groups were monitored and AKI was ascertained as per Acute Kidney Injury Network criteria.
RESULTS
The incidence of AKI was less in therapeutic hypothermia group compared to standard treatment group (32% versus 60%, p < 0.05). The incidence of Stages 1, 2, and 3 AKI was 22%, 5%, and 5% in therapeutic hypothermia group compared with 52%, 5%, and 3%, respectively, in the standard treatment group. The mortality was less in therapeutic hypothermia group compared with the standard treatment group (26% versus 50%, p < 0.05).
CONCLUSION
Therapeutic hypothermia reduces the incidence and severity of AKI among term neonates with perinatal asphyxia.
目的
本研究的目的是评估治疗性低温是否能降低足月围产期窒息新生儿急性肾损伤（AKI）的发生率。
方法
这项在印度南部一家三级护理教学医院进行的随机对照试验纳入了120例足月围产期窒息新生儿，他们被随机分为接受治疗性低温或标准支持治疗两组。监测两组新生儿的肾脏参数，并根据急性肾损伤网络标准确定是否发生AKI。
结果
与标准治疗组相比，治疗性低温组的AKI发生率更低（32%对60%，p<0.05）。治疗性低温组1、2、3期AKI的发生率分别为22%、5%和5%，而标准治疗组分别为52%、5%和3%。与标准治疗组相比，治疗性低温组的死亡率更低（26%对50%，p<0.05）。
结论
治疗性低温可降低足月围产期窒息新生儿AKI的发生率和严重程度。
Zotero 插件