Shen Honghong, Yuan Jinyang, Yang Yang, Liu Xiaozhen, Wang Li, Feng Xiaolong, Zhao Lin, Niu Yun
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Department of General Surgery, Second Affiliated Hospital Shanxi Medical University, Taiyuan, China.
J Surg Oncol. 2015 Nov;112(6):569-74. doi: 10.1002/jso.24062. Epub 2015 Oct 13.
There is a paucity of data examining whether 1-3 positive lymph nodes patients have similar survival outcomes. The present studies separately analyse survival outcomes of T1-2N1 breast cancer patients according to the number of positive lymph nodes.
A total of 1,030 patients with T1-2N1 breast cancer were available for analysis. Survival estimates were calculated using the Kaplan-Meier method, univariate, and multivariate logistic regression models
Kaplan-Meier analysis showed progressively worse survival with the increased number of positive lymph nodes. Log-rank test P values were 0.003 (1 vs. 2 positive LNs), <0.0001 (1 vs. 3), and 0.006 (2 vs. 3) for recurrence-free survival (RFS). Log-rank test P values were 0.045 (1 vs. 2), <0.0001 (1 vs. 3), and 0.018 (2 vs. 3) for metastasis-free survival (MFS). Log-rank test P values were 0.101 (1 vs. 2), <0.0001 (1 vs. 3), and 0.005 (2 vs. 3) for overall survival (OS). Multivariate analysis showed that 3 and 2 positive lymph nodes had worse survival compared with 1 positive axillary lymph nodes.
Our study does suggest that T1-2N1 patients showed progressively worse survival outcomes with the increased number of positive lymph nodes.
关于1 - 3枚阳性淋巴结患者的生存结果是否相似，可供研究的数据较少。本研究分别根据阳性淋巴结数量分析T1-2N1期乳腺癌患者的生存结果。
共有1030例T1-2N1期乳腺癌患者可供分析。采用Kaplan-Meier法、单因素和多因素逻辑回归模型计算生存估计值。
Kaplan-Meier分析显示，随着阳性淋巴结数量增加，生存情况逐渐变差。无复发生存（RFS）的对数秩检验P值分别为：1枚与2枚阳性淋巴结比较为0.003，1枚与3枚比较<0.0001，2枚与3枚比较为0.006。无转移生存（MFS）的对数秩检验P值分别为：1枚与2枚比较为0.045，1枚与3枚比较<0.0001，2枚与3枚比较为0.018。总生存（OS）的对数秩检验P值分别为：1枚与2枚比较为0.101，1枚与3枚比较<0.0001，2枚与3枚比较为0.005。多因素分析显示，与1枚腋窝阳性淋巴结相比，2枚和3枚阳性淋巴结的生存情况更差。
我们的研究确实表明，T1-2N1期患者随着阳性淋巴结数量增加，生存结果逐渐变差。
