Yoshida Y, Oguma S, Uchino H
1st Dept. of Internal Medicine, Faculty of Medicine, Kyoto University.
Gan To Kagaku Ryoho. 1989 Feb;16(2):149-55.
Certain hematopoietic disorders and immunodeficiency states are known to carry a risk of developing acute nonlymphocytic leukemia. In the past some of them have been classified by a variety of terms ranging from refractory anemia to preleukemia, but are currently grouped into a new concept of the myelodysplastic syndromes (MDS). The purpose of this article is to briefly review the updated knowledge of the MDS with emphasis on the clonal origin, natural history and mechanisms of leukemogenesis.
某些造血系统疾病和免疫缺陷状态已知存在发展为急性非淋巴细胞白血病的风险。过去，其中一些疾病曾被用从难治性贫血到白血病前期等各种术语进行分类，但目前它们被归为骨髓增生异常综合征（MDS）这一新概念中。本文的目的是简要回顾MDS的最新知识，重点是其克隆起源、自然病程和白血病发生机制。
