Kudrimoti Jyoti K, Gaikwad Manish J, Puranik Shaila C, Chugh Ashish P
Department of Pathology, BJ Medical College, Pune, Maharashtra, India.
J Cancer Res Ther. 2015 Jul-Sep;11(3):648. doi: 10.4103/0973-1482.146112.
A 42-year-old immunocompetent female presented with headache, vomiting and diminished unilateral vision. Computed tomography and magnetic resonance imaging were suggestive of high-grade meningioma. Neurological examination and routine hematological parameters were within normal limits. Craniotomy was performed; the tumor was arising from the dura mater, which was completely resected. Hematoxylin and eosin showed lesion comprising a tumor mass with monomorphic population of tumor cells arranged in sheets and small follicles. The tumor cells were immunoreactive for leukocyte common antigen and CD20 and immunonegative for glial fibrillary acid protein, epithelial membrane antigen, cytokeratin, CD3 and CD30. Rest of the body scan was normal. A diagnosis of primary dural non-Hodgkin's lymphoma was made. We report this exceedingly rare case of primary dural non-Hodgkin's lymphoma, which mimicked clinically and radiologically as meningioma.
一名42岁免疫功能正常的女性出现头痛、呕吐及单侧视力减退。计算机断层扫描和磁共振成像提示为高级别脑膜瘤。神经系统检查及常规血液学指标均在正常范围内。行开颅手术;肿瘤起源于硬脑膜,已被完全切除。苏木精-伊红染色显示病变为一个肿瘤块,肿瘤细胞单一形态,呈片状和小滤泡状排列。肿瘤细胞对白血细胞共同抗原和CD20呈免疫反应性,对胶质纤维酸性蛋白、上皮膜抗原、细胞角蛋白、CD3和CD30呈免疫阴性。全身其他部位扫描正常。诊断为原发性硬脑膜非霍奇金淋巴瘤。我们报告这例极为罕见的原发性硬脑膜非霍奇金淋巴瘤病例,其在临床和影像学上均酷似脑膜瘤。