Sridevi H B, Shanthala P R, Raghuveer C V, Prabhu Ananth K, Akbar Jallaluddin K C, Shivaprasad G S, Suresh Pooja K, Navani Sanjay
Department of Pathology, Kasturba Medical College, Mangalore, Manipal University, Manipal, India.
J Cancer Res Ther. 2015 Jul-Sep;11(3):656. doi: 10.4103/0973-1482.139338.
Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.
皮肤间变性大细胞淋巴瘤可表现为原发性疾病，也可继发于先前存在的系统性间变性淋巴瘤。将原发性皮肤间变性淋巴瘤（PC-ALCL）与其系统性对应物区分开来需要进行全面的临床和实验室检查。我们在此报告一例年轻成人的PC-ALCL病例，该患者颈部出现异常迅速进展的溃疡性肿块。活检显示间变性大细胞，其CD30和CD25呈强阳性，但ALK1基因产物为阴性。临床检查和计算机断层扫描（CT）排除了皮肤外受累。计划采用CHOP方案进行6个周期的化疗，随访时病变完全缓解。
