氯喹在体外可抑制埃博拉病毒复制，但在体内豚鼠模型中未能预防感染和疾病。
Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model.
作者信息
Dowall Stuart D, Bosworth Andrew, Watson Robert, Bewley Kevin, Taylor Irene, Rayner Emma, Hunter Laura, Pearson Geoff, Easterbrook Linda, Pitman James, Hewson Roger, Carroll Miles W
机构信息
Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
出版信息
J Gen Virol. 2015 Dec;96(12):3484-3492. doi: 10.1099/jgv.0.000309.
Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbreaks in human populations accompanied by significant mortality. Owing to the lack of approved therapies, screening programmes of potentially efficacious drugs have been undertaken. One of these studies has demonstrated the possible utility of chloroquine against EBOV using pseudotyped assays. In mouse models of EBOV disease there are conflicting reports of the therapeutic effects of chloroquine. There are currently no reports of its efficacy using the larger and more stringent guinea pig model of infection. In this study we have shown that replication of live EBOV is impaired by chloroquine in vitro. However, no protective effects were observed in vivo when EBOV-infected guinea pigs were treated with chloroquine. These results advocate that chloroquine should not be considered as a treatment strategy for EBOV.
埃博拉病毒（EBOV）具有高度致病性，易于在人群中引发疫情，并伴有显著的死亡率。由于缺乏获批的治疗方法，人们开展了潜在有效药物的筛选项目。其中一项研究使用假型试验证明了氯喹对埃博拉病毒可能具有效用。在埃博拉病毒病的小鼠模型中，关于氯喹治疗效果的报道相互矛盾。目前尚无使用更大且更严格的豚鼠感染模型来研究其疗效的报告。在本研究中，我们已表明氯喹在体外可抑制活埃博拉病毒的复制。然而，当用氯喹治疗感染埃博拉病毒的豚鼠时，在体内未观察到保护作用。这些结果表明，氯喹不应被视为治疗埃博拉病毒的策略。
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