Sauder D N
Department of Medicine, Division of Dermatology, McMaster University, Hamilton, Ontario, Canada.
Clin Geriatr Med. 1989 Feb;5(1):149-60.
Like other systems in the body, the immune system deteriorates with age. Age-related changes in epidermal immune function include morphologic and functional changes in Langerhans cells, decreased production and response to epidermal thymocyte-activating factor (ETAF), and altered allergic contact dermatitis. These may be primary age-related changes in epidermal immune function or may be secondary to aging of the organism. In either case, the age-related changes in epidermal immunity may contribute to the increased susceptibility to cutaneous infections and neoplasms with advancing age.
与身体中的其他系统一样，免疫系统会随着年龄的增长而衰退。表皮免疫功能的年龄相关变化包括朗格汉斯细胞的形态和功能变化、表皮胸腺细胞激活因子（ETAF）的产生和反应减少，以及过敏性接触性皮炎的改变。这些可能是表皮免疫功能原发性的年龄相关变化，也可能是机体衰老的继发性变化。无论哪种情况，表皮免疫的年龄相关变化都可能导致随着年龄增长皮肤感染和肿瘤易感性增加。
