多能性因子OCT4在犬肥大细胞瘤中的免疫组化表达
Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours.
作者信息
Vargas T H M, Pulz L H, Barra C N, Kleeb S R, Xavier J G, Catão-Dias J L, Fukumasu H, Nishiya A T, Strefezzi R F
机构信息
Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil.
Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
出版信息
J Comp Pathol. 2015 Nov;153(4):251-5. doi: 10.1016/j.jcpa.2015.08.010. Epub 2015 Oct 13.
Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.
癌症干细胞（CSCs）与多种肿瘤的恶性程度及化疗耐药性相关。OCT4是这些细胞所表达的一种“多能性因子”。本研究旨在通过免疫组织化学方法研究OCT4在犬皮肤肥大细胞瘤（MCTs）中的表达情况。对28例病例进行了评估，结果显示免疫标记模式各不相同。这些犬只仅接受了手术治疗，并随访至少180天。组织病理学分级之间未发现显著差异，疾病导致的死亡率及术后生存率也得到了相似结果。这些初步结果表明，OCT4表达并非犬MCT的精确预后指标。
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