Macfarlane M J, Macfarlane L L, Scase T, Parkin T, Morris J S
University of Glasgow, School of Veterinary Medicine, Glasgow, UK.
Bridge Pathology Ltd, Bristol, UK.
Vet Rec. 2016 Nov 12;179(19):491. doi: 10.1136/vr.103650. Epub 2016 Sep 20.
Canine mast cell tumours (MCTs) are variable in their biological behaviour and treatment decisions depend heavily on the histopathological grade. Biomarkers such as neutrophil to lymphocyte ratio (NLR) and albumin to globulin ratio are used to predict the biological behaviour of human neoplasms, but have not been widely studied in dogs. A retrospective analysis identified 62 cases of gross MCT (14 high-grade, 48 low-grade tumours). Median NLR was significantly different between high- and low-grade MCT and tumours at different locations. A multivariable model identified increasing NLR (OR 2.0) and age (OR 1.7) to be associated with an increased risk of high-grade MCT. Receiver operating characteristic curve analysis identified an NLR threshold value of 5.67 (sensitivity 85.7 per cent; specificity 54.2 per cent) for predicting a high-grade MCT. An NLR threshold of 5.67 could be useful alongside existing tools (appearance, location, etc.) to help to predict the grade of MCT. With further validation, this biomarker could be used to guide clinical decisions before obtaining a histopathological diagnosis.
犬肥大细胞瘤（MCTs）的生物学行为具有多样性，治疗决策很大程度上取决于组织病理学分级。中性粒细胞与淋巴细胞比值（NLR）和白蛋白与球蛋白比值等生物标志物可用于预测人类肿瘤的生物学行为，但在犬类中尚未得到广泛研究。一项回顾性分析确定了62例大体MCT病例（14例高级别、48例低级别肿瘤）。高级别和低级别MCT以及不同部位肿瘤之间的NLR中位数存在显著差异。多变量模型确定NLR升高（比值比2.0）和年龄增长（比值比1.7）与高级别MCT风险增加相关。受试者工作特征曲线分析确定预测高级别MCT的NLR阈值为5.67（敏感性85.7%；特异性54.2%）。NLR阈值5.67可与现有工具（外观、位置等）一起用于帮助预测MCT的分级。经过进一步验证，这种生物标志物可用于在获得组织病理学诊断之前指导临床决策。
