用于衰老认知病理学鉴别诊断的自传体记忆。
Autobiographical memory for the differential diagnosis of cognitive pathology in aging.
作者信息
Meléndez Juan C, Redondo Rita, Torres Marta, Mayordomo Teresa, Sales Alicia
机构信息
Department of Developmental Psychology, Faculty of Psychology, University of Valencia, Valencia, Spain.
Department of Methodology for the Behavioral Sciences, Faculty of Psychology, University of Valencia, Valencia, Spain.
出版信息
Geriatr Gerontol Int. 2016 Nov;16(11):1220-1225. doi: 10.1111/ggi.12611. Epub 2015 Oct 13.
AIM
The present study distinguishes three memory stages across the lifespan, and aims to compare episodic and semantic autobiographical memory in healthy older adults, with amnesic mild cognitive impairment, and with Alzheimer's disease. This information can offer evidence about the way semantic and episodic autobiographical memory work, and how the disease affects them.
METHODS
The sample was composed of 56 people, all aged over 60 years; 15 with amnestic mild cognitive impairment, 12 with Alzheimer's disease and 29 healthy older people. Participants were evaluated with the Autobiographical Memory Interview.
RESULTS
A mixed anova showed significant main effects of memory and time-period, and significant interactions of memory × group, time-period × group and memory × time × group.
DISCUSSION
Assessment of autobiographical memory provides information to differentiate amnestic mild cognitive impairment patients from Alzheimer's disease patients. Although the decline in episodic memory starts with the onset of the disease, semantic memory is maintained until moderate stages of dementia. Geriatr Gerontol Int 2016; 16:1220-1225.
目的
本研究区分了一生中的三个记忆阶段，旨在比较健康老年人、遗忘型轻度认知障碍患者以及阿尔茨海默病患者的情景性和语义性自传体记忆。这些信息可为语义性和情景性自传体记忆的工作方式以及疾病如何影响它们提供证据。
方法
样本由56名年龄均超过60岁的人组成；15名遗忘型轻度认知障碍患者、12名阿尔茨海默病患者和29名健康老年人。参与者接受了自传体记忆访谈评估。
结果
混合方差分析显示记忆和时间段有显著主效应，以及记忆×组、时间段×组和记忆×时间×组的显著交互作用。
讨论
自传体记忆评估为区分遗忘型轻度认知障碍患者和阿尔茨海默病患者提供了信息。尽管情景记忆的衰退始于疾病发作，但语义记忆在痴呆的中度阶段之前仍得以保持。《老年医学与老年病学国际杂志》2016年；16:1220 - 1225。
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