Department of Developmental and Educational Psychology, Faculty of Psychology, University of Valencia, Av. Blasco Ibañez 21, ES 46010 Valencia, Spain.
Department of Methodology of the Behavioral Sciences, Faculty of Psychology, University of Valencia, Av. Blasco Ibañez 21, ES 46010 Valencia, Spain.
Int J Environ Res Public Health. 2021 Jun 25;18(13):6849. doi: 10.3390/ijerph18136849.
The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer's disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months.
Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer's disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview.
The results showed significant longitudinal deterioration in episodic and semantic autobiographical memory in patients with mild cognitive impairment and in patients with Alzheimer's disease, but not in healthy older adults.
The deterioration of episodic and semantic autobiographical memory in AD is confirmed; however, although the episodic was impaired in aMCI, a pattern that evolved toward deterioration over a period of eighteen months was observed for the semantic autobiographical memory.
本研究的主要目的是分析轻度认知障碍患者、阿尔茨海默病患者和健康对照组患者自传体记忆（情节和语义）的演变。我们在两个时间点比较了这些组：首先，在基线时，然后在 18 个月后的随访时。
在两个时间点，我们评估了 26 名健康的老年成年人、17 名轻度遗忘型认知障碍患者和 16 名阿尔茨海默病患者，这些患者在年龄和教育程度上相匹配，使用自传体记忆访谈。
结果显示，轻度认知障碍患者和阿尔茨海默病患者的情节和语义自传体记忆在纵向均有明显恶化，但健康老年人没有。
AD 患者的情节和语义自传体记忆恶化得到证实；然而，虽然 aMCI 患者的情节记忆受损，但语义自传体记忆在 18 个月的时间内呈现出恶化的趋势。
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